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Unraveling the Neurobiological Pathways Linking Childhood Trauma to Bipolar Disorder: Insights from the ENIGMA Consortium
Neurologybrain morphologycortical thickness

Unraveling the Neurobiological Pathways Linking Childhood Trauma to Bipolar Disorder: Insights from the ENIGMA Consortium

By MedXY|Aug 12, 2026

An international study reveals that childhood trauma’s association with bipolar disorder is partially mediated by brain morphology changes, particularly in hippocampal volume and frontal cortical thickness.

Neurologyamyloidcognitive decline

Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study

By MedXY|Jun 17, 2026

The POINTER Imaging study found no overall brain biomarker changes from a structured lifestyle intervention, but participants with lower baseline hippocampal volume showed greater cognitive benefit, suggesting imaging may help identify who

High‑Intensity Interval Training Fails to Rescue Hippocampal Integrity in Adults With Cannabis Use Disorder — but Exercise Is Feasible and May Reduce Craving
Neurologycannabis use disorderexercise

High‑Intensity Interval Training Fails to Rescue Hippocampal Integrity in Adults With Cannabis Use Disorder — but Exercise Is Feasible and May Reduce Craving

By MedXY|Nov 14, 2025

A randomized trial in adults with moderate–severe cannabis use disorder found 12 weeks of supervised HIIT did not improve a composite MRI measure of hippocampal integrity versus strength/resistance training; exercise participation was feasi

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