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A large-scale phenotypic screen of 9,139 knockout mouse lines identified 18 candidate genes linked to retinal and hearing abnormalities, offering promising new targets for understanding and diagnosing Usher syndrome.
The CHOICE trial investigated whether hearing aid intervention reduces dementia progression in older adults with mild cognitive impairment and hearing loss, finding no significant reduction in dementia incidence but increased cognitive impr
This review synthesizes evidence linking hearing loss to regional brain amyloid deposition, highlighting recent in vivo PET findings, meta-analytic data on AD neuropathology, and amyloid-related inner ear pathology, discussing potential mec
Researchers developed a novel 4-level classification system using routine audiometric data to estimate cochlear implant candidacy likelihood, moving beyond traditional binary screening approaches to support personalized shared decision-maki
A visual-world eye-tracking study in older adults shows that postlingual hearing loss delays verb-driven semantic prediction—especially under higher listening demand—while simple agent-based prediction is preserved.
A PRISMA systematic review and meta-analysis of 17 studies (2019–2024) found type 2 diabetes is associated with a 4.19-fold greater odds of hearing loss, especially at high frequencies; duration >10 years and higher HbA1c amplified risk.
Regeneron’s DB-OTO gene therapy shows promising results in restoring natural hearing in children with profound hearing loss caused by OTOF gene mutations, with 75% achieving significant hearing improvement after a single treatment.
