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Early continuous creatinine changes within 48 hours after EVT correlate with graded risks of poor 90-day functional outcome and in-hospital mortality, revealing prognostic nuances beyond traditional dichotomous CA-AKI definitions.
SGLT2 inhibitors administered after endovascular thrombectomy in diabetic stroke patients significantly improve 3-month functional outcomes, suggesting a promising adjunctive therapy for poststroke diabetes management.
A phase IIb trial shows that adding normobaric hyperoxia to endovascular thrombectomy in acute ischemic stroke patients 6 to 24 hours after onset is safe, improves early neurological outcomes, and reduces infarct volume, warranting larger c
Intensive blood pressure lowering post-thrombectomy increases acute kidney injury risk, which correlates with poorer neurological outcomes in stroke patients. Careful BP management is crucial to prevent renal complications and optimize reco
This study identifies a volumetric threshold of 110 mL infarct size beyond which the benefit of thrombectomy diminishes, advocating volumetric assessment over ASPECTS scoring to optimize treatment selection and outcomes in large-core stroke
Recent evidence identifies volumetric thresholds surpassing ASPECTS scoring for optimizing thrombectomy candidacy in large-core ischemic stroke, highlighting a therapeutic ceiling at infarct volumes ≥110 mL.
In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.
In OPTIMAL-BP 1-year follow-up, targeting systolic BP <140 mm Hg after successful thrombectomy was associated with worse long-term functional recovery than conventional BP management.
In the IAT-TOP randomized trial, intra-arterial alteplase after successful EVT for acute basilar artery occlusion did not improve 90-day functional independence, while symptomatic intracranial hemorrhage and mortality were similar between g
Endovascular thrombectomy (EVT) significantly improves 90-day functional outcomes in acute anterior cerebral artery occlusion stroke compared to standard medical management, without increasing hemorrhage or mortality risks, per the ORIENTAL
In patients aged under 80 with ASPECTS 0-2, endovascular thrombectomy improved disability outcomes and reduced mortality versus medical care alone, challenging the idea that very large infarcts should automatically exclude treatment.
The multicenter TASTE-2 trial reveals that edaravone dexborneol significantly increases the likelihood of functional independence at 90 days for acute ischaemic stroke patients undergoing thrombectomy, particularly those presenting with a c
The 3-year outcomes of the ATTENTION trial confirm that endovascular thrombectomy for acute basilar artery occlusion provides durable functional benefits and significantly reduces mortality compared to medical management, establishing its l
A large-scale prospective study across England’s NHS reveals that AI imaging software significantly boosts endovascular thrombectomy rates for acute stroke patients. Implementation was associated with a 100% relative increase in treat
An IPD meta-analysis of six randomized trials (2313 patients) found IV alteplase before EVT modestly increased intracranial hemorrhage—particularly parenchymal hematoma—yet ICH risk must be balanced against IVT-associated improvements in re
A 523‑patient multicenter cohort found intravenous thrombolysis alone was associated with better 3‑month functional outcomes and lower mortality than endovascular thrombectomy (± IVT) for acute basilar artery occlusion after adjustment for
Adjunctive intra-arterial tenecteplase after successful reperfusion in anterior circulation large vessel occlusion stroke demonstrates an acceptable safety profile at low doses, supporting further investigation into its therapeutic potentia
