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Berberine is a naturally occurring chemical compound extracted from various plants within the Berberis genus, including goldenseal, barberry, and Oreg
Dihydroberberine demonstrates superior absorption compared to berberine, suggesting enhanced pharmacological properties. Recent studies highlight its potential in metabolic and inflammatory diseases, warranting further clinical exploration.
This review synthesizes the latest 5-year evidence on dihydroberberine, highlighting improved bioavailability over berberine, mechanistic insights from metabolic and network pharmacology studies, and its promising clinical applications in m