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Gastroenterology

Dietary Intervention Lowers Intestinal Inflammation in High-Risk Relatives of Crohn’s Disease Patients: Insights from the PIONIR Trial

The PIONIR randomized crossover trial demonstrates that a specific Tasty&Healthy diet significantly reduces fecal calprotectin levels, a marker of gut inflammation, in first-degree relatives at high risk for Crohn’s disease, sugge

Nov 3, 2026
Gastroenterology

Confocal Laser Endomicroscopy-Guided Exclusion Diet Fails to Improve IBS Symptoms in Controlled Trial

A randomized controlled crossover trial found that individualized exclusion diets based on confocal laser endomicroscopy (CLE) findings do not significantly improve symptoms in irritable bowel syndrome (IBS) patients compared to sham diets.

Sep 5, 2026
Cardiology

Culturally Tailored Meal Program Reduces Hospitalizations in Navajo Patients With Heart Failure: The MUTTON-HF Trial

In a randomized trial among Navajo patients with heart failure, an 8-week culturally tailored meal program reduced all-cause hospitalization or ED visits by 28% compared with usual dietary advice, with improvements in quality of life and food security.

Jul 29, 2026
Allergy & Immunology

Dynamic Effects of Short-Term Dietary Energy Loads on Fecal Serotonin, Gut Microbiome Tryptophanase, and Energy Absorption: Insights from a Randomized Crossover Trial

Short-term alterations in dietary energy intake significantly impact fecal serotonin, gut microbiome tryptophanase activity, and energy absorption, highlighting a complex interaction that may influence metabolic health.

Sep 16, 2025

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