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The effectiveness of lifestyle interventions promoting physical activity for diabetes risk reduction varies by prediabetes phenotype, with individuals having impaired fasting glucose showing the least response. Tailored approaches may enhan
Early weight loss after impaired glucose tolerance diagnosis is linked to markedly reduced long-term risk of cardiovascular events and death, underscoring the importance of early lifestyle interventions in prediabetes management.
The ELSA-Brasil study found that staging intermediate hyperglycaemia with fasting glucose plus 1-hour glucose better predicted type 2 diabetes than fasting glucose plus HbA1c, and a clinical risk score reduced unnecessary testing.
A major long-term trial reveals that a moderate-protein, moderate-glycaemic index diet is more effective for sustaining prediabetes remission than high-protein alternatives, regardless of total weight loss.
A post hoc analysis of PLIS and replication in the DPP show that achieving prediabetes remission—normalization of glucose—can prevent type 2 diabetes even without net weight loss, via improved insulin sensitivity, β‑cell function and favora
This review examines the first phase 3 randomized trial demonstrating that an AI-powered Diabetes Prevention Program lifestyle intervention is noninferior to human coaching in improving weight loss, HbA1c, and physical activity among adults
