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Impact of CYP2D6 and CYP2C19 Genetic Variations on Venlafaxine Treatment Outcomes: Insights from Norwegian and UK Cohorts

This article reviews a large retrospective study revealing significant associations between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure, highlighting the potential for genotype-guided personalized antidepressant therapy.

Oct 17, 2026
Anesthesiology

Precision Medicine Fails to Improve Postoperative Pain: Insights from the CYP2D6-Guided Opioid Trial

A randomized clinical trial demonstrates that while CYP2D6 genotyping significantly shifts opioid prescribing patterns for poor and intermediate metabolizers, it does not improve pain control or reduce opioid consumption within the context

Feb 23, 2026

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