CYP2C19

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Impact of CYP2D6 and CYP2C19 Genetic Variations on Venlafaxine Treatment Outcomes: Insights from Norwegian and UK Cohorts

This article reviews a large retrospective study revealing significant associations between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure, highlighting the potential for genotype-guided personalized antidepressant therapy.

Oct 17, 2026

Gastroenterology

Impact of CYP2C19 Polymorphisms on Medical and Surgical Management of GERD: Implications for Personalized Therapy

A study reveals a higher prevalence of rapid CYP2C19 metabolizer phenotypes in GERD patients undergoing surgery versus medical therapy, supporting tailored proton pump inhibitor dosing and timely surgical referral.

Aug 24, 2026Sign in to read

Diabetes & Endocrinology

High Insulin Resistance Blunts the Superiority of Ticagrelor Over Clopidogrel in Minor Stroke Patients with CYP2C19 Mutations

A post hoc analysis of the CHANCE-2 trial suggests that the clinical benefit of ticagrelor over clopidogrel for secondary stroke prevention in CYP2C19 loss-of-function carriers is significantly attenuated in patients with high insulin resis

Jan 22, 2026