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A large-scale longitudinal study reveals that α-synuclein seed amplification assay (SAA) kinetic measures, particularly time to threshold, can differentiate Parkinson’s from PSP and predict future cognitive decline independently of Al
This review synthesizes recent large-scale multi-cohort studies revealing white matter microstructural abnormalities—especially free water increases—in limbic tracts as critical markers of cognitive decline in aging and Alzheimer’s di
Elevated high-sensitivity cardiac troponin I and T levels, indicative of subclinical myocardial injury in midlife, are associated with accelerated cognitive decline, structural brain changes, and increased dementia risk in later life.
A scoping review found sparse and inconsistent mediation analyses assessing cardiovascular disease as the pathway linking lifestyle factors to cognition; evidence is tentative for physical activity but urgent, better-designed studies are ne
Elevated vitamin B12 levels from mid- to late life correlate with reduced rates of cognitive decline across language, memory, and executive function domains, independent of folate status, highlighting potential preventative strategies again
In MESA, baseline subclinical arteriosclerosis and atherosclerosis scores predicted greater cognitive decline and higher odds of MCI/dementia over 20 years, independently of clinical dementia risk factors.
New research reveals that quitting smoking in mid to late life significantly slows cognitive decline, offering an added three years of brain health regardless of quitting age.
This review evaluates recent evidence on plasma AD biomarkers, especially phosphorylated tau217 and amyloid PET, for predicting cognitive decline in unimpaired individuals, highlighting their potential and limitations.
This study reveals that APOE4 carriers with elevated blood neurodegenerative biomarkers experience accelerated cognitive decline, highlighting the gene’s role in exacerbating neurodegeneration among community-dwelling older adults wit
This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African popula
A large-scale network meta-analysis highlights that combined physical exercise and cognitive training most effectively improve cognition in older adults without impairment, emphasizing tailored lifestyle strategies for dementia prevention.
Smoking cessation in middle-aged and older adults is linked to a slower decline in memory and fluency over six years, suggesting quitting smoking benefits long-term cognitive health regardless of age at cessation.
Childhood loneliness significantly increases the risk of cognitive decline and dementia in middle-aged and older adults, independent of adult loneliness, highlighting the importance of early psychosocial interventions.
This article explores the genetic data resource from the MIND trial, highlighting its potential to tailor dietary interventions to mitigate cognitive decline and advance precision nutrition for Alzheimer’s risk populations.
Long-term studies reveal that proper supplementation of B vitamins can slow brain atrophy, improve cognitive function, and reduce dementia risk, especially in older adults at risk of deficiency.
This review synthesizes the Menopause Priority Setting Partnership findings, highlighting the top ten evidence-based research priorities addressing non-hormonal treatments, lifestyle interventions, cognitive and sleep changes, hormone thera
Discover 13 scientifically-supported foods that can help protect and enhance cognitive function, potentially reducing dementia risk as you age.
This longitudinal study reveals persistent cognitive, physical, and vascular challenges up to 9 years after minor lacunar or cortical ischemic stroke, emphasizing different risks and recovery patterns by stroke subtype.
Regular physical activity in early Parkinson disease patients is linked to slower brain atrophy in temporoparietal and limbic regions, mediating better preservation of memory and attention over four years.
A longitudinal study reveals that α-synuclein seed amplification assay kinetic measures enhance diagnostic accuracy and predict cognitive decline in Parkinson’s disease, independent of Alzheimer’s co-pathology.
