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A large-scale retrospective study reveals that while previous abdominal surgeries do not compromise weight loss after bariatric procedures, they significantly increase intraoperative complexity, operative time, and the risk of postoperative
A large-scale analysis of 239,890 patients in England reveals that Black, Asian, and mixed-ethnicity patients hospitalized for heart failure have significantly lower mortality rates than White patients, largely due to better pharmacological
A large-scale retrospective study in Ontario indicates that solid-organ transplant recipients, particularly kidney transplant patients, experience significantly better outcomes for emergency general surgery conditions when treated at specia
A large-scale retrospective study reveals that anxiety and depression following the diagnosis of unruptured intracranial aneurysms significantly increase the risk of rupture and all-cause mortality, suggesting that integrated psychiatric as
This systematic review and meta-analysis evaluates 15 HS-specific PROMs using the COSMIN framework, identifying 7 recommended instruments and highlighting the superior psychometric performance of HiSQOL-17 while uncovering significant gaps
This article examines the 20-year safety and efficacy of transcatheter PFO closure in patients with paradoxical embolism, highlighting low recurrence rates but significant long-term bleeding risks associated with antithrombotic therapy.
A large-scale matched cohort study from the UK Biobank identifies in-hospital delirium as a sentinel marker for long-term multisystem vulnerability. Associated with increased risks of sepsis, AKI, and falls, delirium signals a profound phys
Researchers in England have developed and validated multivariable risk adjustment models for ROSC and survival following out-of-hospital cardiac arrest. These models provide a robust framework for benchmarking EMS performance and driving qu
A prospective study reveals that patients with mental health conditions face significant delays in STEMI diagnosis, resulting in larger infarct sizes and a twofold increase in five-year cardiovascular mortality compared to those without suc
A large-scale study of US veterans demonstrates that oral magnesium therapy significantly improves outcomes in heart failure patients with hypomagnesemia, especially those with levels below 1.3 mg/dL. Conversely, supplementation in normomag
The multicentre OCCUPI trial showed OCT-guided PCI reduced 1‑year major adverse cardiac events versus angiography (HR 0.62). A prespecified OCT subanalysis found that achieving predefined OCT optimization (expansion, apposition, no major ed
In the OCCUPI trial, achievement of predefined OCT optimization criteria after OCT‑guided PCI for complex coronary lesions was associated with a large reduction in 1‑year major cardiac events versus sub‑optimized cases and angiography guida
The ALIGN-AR studies demonstrate that transcatheter aortic valve implantation using the Trilogy valve is a safe and effective treatment for symptomatic native moderate-to-severe or severe aortic regurgitation in patients at high surgical ri
Continued oral anticoagulant therapy after ≥90 days for unprovoked VTE significantly lowers recurrence and mortality despite increased bleeding risk, offering a net clinical benefit consistent across anticoagulant types and treatment durati
Hypertension independently worsens clinical outcomes and liver fibrosis progression in MASLD, highlighting the need for integrated cardiovascular and hepatic care.
The SIPS surgical handover system significantly improves handover quality, patient vital signs, and staff safety perceptions without prolonging meeting times, enhancing safety in emergency general surgery.
In primary biliary cholangitis (PBC) patients treated with obeticholic acid (OCA), biochemical non-response strongly predicts a higher risk of clinical events including liver decompensation and mortality, underscoring the need for improved
The MITRACURE registry reveals late-stage referral and suboptimal early intervention in mitral regurgitation surgery, highlighting the need for improved management strategies to enhance repair rates and reduce mortality.
The MITRACURE international registry reveals that mitral valve surgery patients often present late in disease progression with advanced symptoms, showing modest repair rates and notable in-hospital mortality, underscoring the need for earli
This international multicenter study evaluates total neoadjuvant therapy (TNT) in routine clinical practice for stage II/III rectal adenocarcinoma, demonstrating varied regimen use and confirming TNT’s efficacy across treatment strategies.
