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This longitudinal study shows that retinal microvascular changes measured by OCTA correspond with cerebral small vessel disease progression and cognitive decline in mild ischemic stroke patients, highlighting OCTA’s potential as a non
This study identifies glycine and specific lipid cholesterol proportions as metabolomic markers causally linked to lacunar stroke subtypes, enhancing understanding of cerebral small vessel disease pathogenesis and potential biomarkers.
Diffusion MRI detects microstructural brain changes up to 16 years before white matter hyperintensities appear, offering a valuable early window for cerebral small vessel disease intervention and improved risk stratification.
DWI-positive lesions in acute intracerebral hemorrhage patients correlate with cerebral small vessel disease markers and predict poorer 6-month outcomes, with lesion distribution varying by small vessel disease subtype.
A large-scale prospective study identifies high basal ganglia perivascular space (BGPVS) burden as a significant predictor of both major bleeding and ischemic stroke in patients on antithrombotic regimens, offering a new imaging biomarker f
A large prospective study reveals that a high burden of basal ganglia enlarged perivascular spaces (BGPVSs) significantly increases the risk of both ischemic stroke and major bleeding in patients on antithrombotic therapy, positioning BGPVS
Elevated plasma glial fibrillary acidic protein (GFAP) in middle age independently predicts the progression of cerebral small vessel disease MRI markers nearly a decade later, suggesting its potential as an early-stage prognostic biomarker
Enlarged perivascular spaces (EPVS) correlate with serum biomarkers of neuroinflammation and amyloid pathology and associate with cognitive impairment, supporting their role as early MRI markers for Alzheimer disease (AD) vascular contribut
