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Survival Estimates and Predictors in Genetic Frontotemporal Dementia: Insights from an International Retrospective Cohort Study
Clinical UpdatesneurodegenerationC9orf72

Survival Estimates and Predictors in Genetic Frontotemporal Dementia: Insights from an International Retrospective Cohort Study

By MedXY|Aug 5, 2026

This review synthesizes international evidence on survival in genetic frontotemporal dementia (FTD), highlighting key predictors such as age at onset, clinical phenotype, and motor symptoms, and discusses implications for patient care and t

Purine Biosynthetic Enzyme PAICS as a Central Mediator of DNA Damage and Cerebellar Atrophy in C9orf72-ALS
Clinical UpdatesALSC9orf72
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Purine Biosynthetic Enzyme PAICS as a Central Mediator of DNA Damage and Cerebellar Atrophy in C9orf72-ALS

By MedXY|Mar 11, 2026

This review synthesizes recent evidence identifying PAICS downregulation as a critical link between C9orf72 loss-of-function, DNA repair failure, and cerebellar neurodegeneration, highlighting its potential as a therapeutic target.

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