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This study highlights the limitations of insulin dose-adjusted hemoglobin A1c (IDAA1c) ≤9 in detecting partial remission in US youth with type 1 diabetes, especially those with overweight or obesity, suggesting BMI-specific adjustments impr
Detectable C-peptide levels indicating residual insulin production strongly correlate with lower diabetic ketoacidosis risk in type 1 diabetes, highlighting the importance of preserving beta-cell function for improved clinical outcomes.
This study highlights that higher baseline and maintained C-peptide levels in type 1 diabetes are linked to reduced risks of acute complications and retinopathy, underscoring the importance of preserving endogenous insulin secretion.
This article examines real-world data on low-dose antithymocyte globulin in type 1 diabetes, assessing beta-cell function via a novel C-peptide modified quantitative response (mQR). Findings suggest feasibility, safety, and potential clinic
Serial dried blood spot C-peptide sampling detects early β-cell preservation in new-onset type 1 diabetes more sensitively than urine C-peptide-to-creatinine ratio or mixed-meal tolerance test.
A pooled analysis of nine type 1 diabetes trials found that beta cell glucose sensitivity may better predict response to disease-modifying therapy than C-peptide alone, helping identify patients most likely to benefit.
Dynamic C-peptide patterns during OGTT uncover metabolic heterogeneity in GDM, identifying insulin-resistant women at risk for fetal overgrowth and normoglycemic women at risk for preeclampsia, suggesting improved stratified treatment beyon
