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This statewide cohort study reveals significantly higher incidence and earlier onset of systemic physical multimorbidity among people with schizophrenia-spectrum or bipolar disorders compared to matched controls, highlighting urgent needs f
An international study reveals that childhood trauma’s association with bipolar disorder is partially mediated by brain morphology changes, particularly in hippocampal volume and frontal cortical thickness.
This study uses advanced 7Li MRI to reveal how brain lithium kinetics closely track serum levels in bipolar disorder patients under once- versus twice-daily lithium dosing, highlighting implications for dosing schedules and therapeutic moni
A multisite case-control study found repulsive serial bias in schizophrenia, attractive bias in healthy controls, and mixed patterns in bipolar disorder, supporting serial dependence as a potential cognitive biomarker across the psychosis s
Researchers developed a clinical prediction model using electronic health records from over 127,000 patients to identify individuals at risk of psychotic or bipolar disorders. The model demonstrated high discriminative power (C-index 0.80)
A large, pragmatic randomized trial found that adjunctive metformin produced a modest but statistically significant reduction in BMI Z-score at 6 and 24 months among overweight and obese youth with bipolar spectrum disorders treated with se
This systematic review evaluates lithium’s efficacy in reducing suicidal ideation, attempts, and completed suicide, highlighting methodological challenges and the likelihood of benefit despite lack of statistical significance in RCTs.
