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Antidepressant Continuation During Pregnancy and Its Impact on Postpartum Depression Risk Across Diverse Populations
Clinical Updatesracial disparitiesPregnancy

Antidepressant Continuation During Pregnancy and Its Impact on Postpartum Depression Risk Across Diverse Populations

By MedXY|Aug 4, 2026

Continuing antidepressants in pregnancy lowers postpartum depression risk irrespective of race or ethnicity; prenatal depressive symptoms severity is critical for personalized treatment.

Decoding Antidepressant Response: Genetic and Phenotypic Markers of Treatment Complexity and Sustained Use
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Decoding Antidepressant Response: Genetic and Phenotypic Markers of Treatment Complexity and Sustained Use

By MedXY|Jan 31, 2026

A large-scale retrospective cohort study identifies specific phenotypic traits and genetic markers, including the SLAMF3/LY9 locus, that predict antidepressant treatment complexity and sustained use, offering a roadmap for precision psychia

Slow Tapering with Psychological Support Matches Medication Continuation for Relapse Prevention in Remitted Depression
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Slow Tapering with Psychological Support Matches Medication Continuation for Relapse Prevention in Remitted Depression

By MedXY|Dec 19, 2025

A landmark network meta-analysis demonstrates that slow antidepressant tapering (>4 weeks) combined with psychological support is as effective as drug continuation in preventing relapse, providing a safe, evidence-based pathway for patie

Not All Antidepressants Are the Same: Differential Cardiometabolic and Physiological Effects from a Large Network Meta‑analysis
Cardiologyantidepressantscardiometabolic risk

Not All Antidepressants Are the Same: Differential Cardiometabolic and Physiological Effects from a Large Network Meta‑analysis

By MedXY|Nov 10, 2025

A 151‑trial network meta‑analysis of 58,534 participants shows marked differences among 30 antidepressants in weight, blood pressure, heart rate, lipids, glucose and liver enzymes; findings support individualized choice and targeted baselin

Evaluating Antidepressant Impact on Bipolar Depression: Insights from a Propensity Score Analysis in the STEP-BD Cohort
newsantidepressantsBipolar Depression

Evaluating Antidepressant Impact on Bipolar Depression: Insights from a Propensity Score Analysis in the STEP-BD Cohort

By MedXY|Oct 27, 2025

A propensity score analysis of STEP-BD data reveals no significant association between antidepressant use and either manic switch risk or symptomatic remission in bipolar depression, highlighting the need for alternative treatment strategie

Long-Term Exposure to Air Pollution and Road Traffic Noise: Associations with Antidepressant Medication Dispensing in Swedish Adults
Clinical Updatesair pollutionantidepressants

Long-Term Exposure to Air Pollution and Road Traffic Noise: Associations with Antidepressant Medication Dispensing in Swedish Adults

By MedXY|Oct 23, 2025

This review synthesizes evidence linking long-term air pollution and road traffic noise exposure with antidepressant medication dispensing, highlighting sex-specific associations and implications for mental health prevention strategies.

FDA Panel Reviews SSRI Use During Pregnancy: Balancing Fetal Risks and Maternal Mental Health
Medical Newsantidepressantsperinatal depression

FDA Panel Reviews SSRI Use During Pregnancy: Balancing Fetal Risks and Maternal Mental Health

By MedXY|Sep 30, 2025

An FDA expert panel debates the risks and benefits of SSRI antidepressants in pregnancy, emphasizing the need to weigh untreated depression risks against potential drug-related fetal outcomes.

SSRIs and Pregnancy: Navigating the Risks, Benefits, and Ongoing Debate
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SSRIs and Pregnancy: Navigating the Risks, Benefits, and Ongoing Debate

By MedXY|Sep 30, 2025

A new FDA panel reignites debate over the safety and efficacy of antidepressant use during pregnancy, with experts weighing in on emerging research and practice recommendations.

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