Tag
PHH-1V, a protein-based COVID-19 vaccine, is shown to be a safe and effective heterologous booster in adolescents, generating strong and lasting immune responses against multiple virus variants.
This retrospective study reveals that psychological readiness, measured by ACL-RSI scores, significantly predicts return to sport in adolescent patients after patellar stabilization surgery, overshadowing demographic and surgical factors.
The LATA trial demonstrates that long-acting injectable cabotegravir-rilpivirine given every 8 weeks is superior to daily oral ART for maintaining virological suppression in adolescents with HIV in sub-Saharan Africa, with a favorable safet
This review synthesizes phase 2 and 3 trial data demonstrating that the pentavalent MenABCWY vaccine is immunologically non-inferior and well tolerated compared with MenB-fHbp and MenACWY-CRM vaccines, offering a simplified, effective vacci
The DIADEMA trial demonstrates dulaglutide’s superiority over insulin in improving glycaemic variability, pancreatic function, and iron overload, without safety concerns, in adolescents with thalassaemia-induced diabetes.
A Finnish registry cohort (n=913,149) found that exposure to same-grade schoolmates’ self-harm modestly increased later self-harm risk (HR 1.05), with the largest effect around age 16 (HR ~1.45), suggesting time-limited social transmi
A 1,565‑participant pragmatic randomized trial shows metformin added to lifestyle counseling produced modest but statistically significant reductions in BMI Z-score at 6 and 24 months in overweight/obese children and adolescents with bipola
A large, pragmatic randomized trial found that adjunctive metformin produced a modest but statistically significant reduction in BMI Z-score at 6 and 24 months among overweight and obese youth with bipolar spectrum disorders treated with se
Comparative effectiveness evidence from multicenter pediatric emergency departments demonstrates that targeted and universally offered gonorrhea and chlamydia screening increase detection rates versus usual care, highlighting the need for i
Stimulant use disorder diagnoses in young adult Medicaid enrollees have markedly increased from 2001 to 2020, especially for noncocaine psychostimulants, highlighting an urgent need for targeted interventions and evidence-based treatments a
Aerobic exercise significantly alleviates depressive symptoms in children and adolescents, especially in diagnosed adolescents, with 590 METs-min/week at moderate intensity identified as the optimal dose.
The ORION-13 trial demonstrates that inclisiran significantly lowers LDL cholesterol by 33.3% and is safe and well tolerated in adolescents with homozygous familial hypercholesterolemia, addressing an unmet pediatric treatment need.
Vietnamese adolescents face notable mental health challenges amid growing social media influence. This article explores the alarming statistics, the stigma surrounding mental health, and the emerging role of social media in providing suppor
Recent meta-analysis finds no significant benefit of standalone safety planning interventions in reducing suicidal ideation or behavior among adolescents, highlighting the need for more robust research.
