SUPREMO Ten-Year Results: Chest‑Wall Irradiation After Mastectomy Lowers Local Recurrence but Does Not Improve 10‑Year Survival in Intermediate‑Risk Breast Cancer
Highlights
– The SUPREMO randomized phase 3 trial (n≈1607) compared chest‑wall irradiation versus omission after mastectomy in intermediate‑risk breast cancer and found no improvement in 10‑year overall survival (OS).
– Chest‑wall irradiation halved the hazard of local (chest‑wall) recurrence (absolute difference <2%) but produced no meaningful difference in disease‑free survival or distant metastasis‑free survival at 10 years.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.