Safety of Biopsy in Pheochromocytoma and Paraganglioma: What a Global Study Found

Safety of Biopsy in Phaeochromocytoma and Paraganglioma

Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that can produce excess catecholamines such as adrenaline and noradrenaline. Because these hormones can trigger severe blood pressure spikes, dangerous heart rhythms, or other complications, biopsy has traditionally been discouraged when PPGL is suspected. This international multicentre study re-examined that long-standing caution by looking at real-world biopsy outcomes across multiple hospitals and countries.

Why biopsy has been controversial