Predictive Factors for Diabetes Outcomes One Year After Total Pancreatectomy with Islet Autotransplantation: Insights from a Large Multicenter Study

Highlight

• At one year post-TPIAT, 83% of patients retained islet graft function evidenced by measurable C-peptide levels.
• Pretransplant HbA1c and pediatric age significantly predicted insulin independence at one year.
• Lower baseline HbA1c was strongly associated with better glycemic control (HbA1c <7%) and improved islet graft function.
• White race was also linked to higher odds of achieving target HbA1c levels postoperatively.

Study Background and Disease Burden