Preconception Trace Metal Profiles in Couples: A New Frontier in Optimizing IVF Embryological Outcomes

Highlights of the Research

The study demonstrates that preconception plasma trace metal levels in both partners significantly influence early IVF embryological outcomes. Key findings include:

• High exposure to trace metal mixtures in couples and male partners is associated with a decrease in best-quality embryos and blastocyst numbers.
• Specific individual elements show divergent effects: Iron (Fe), Lithium (Li), Strontium (Sr), and Molybdenum (Mo) are positively associated with favorable embryological outcomes.
• Conversely, Silver (Ag) and Thallium (Tl) were identified as harmful elements, negatively impacting fertilization and embryo development.
• The study underscores the necessity of a couple-based approach, rather than focusing solely on maternal health, to optimize assisted reproductive technology (ART) success.