Precision Nutrition, Neoadjuvant Oncology, and Prehospital Analgesia: Key Clinical Milestones from the 2025 Lancet Series

Highlights

• The EAT-Lancet planetary health diet is nutritionally adequate for most micronutrients in population-based settings, though it poses an increased risk of anemia for women.
• The neoadjuvant PAXG quadruplet chemotherapy regimen significantly improves event-free survival (EFS) compared to mFOLFIRINOX in resectable and borderline resectable pancreatic ductal adenocarcinoma (PDAC).
• Inhalational methoxyflurane has been proven non-inferior to intravenous morphine and superior to intranasal fentanyl for rapid prehospital pain relief.
• Standardization of dietary scoring and energy adjustment is critical for interpreting the health impacts of sustainable nutrition frameworks.

Background