Pembrolizumab plus Lenvatinib Shows Promising Activity but Substantial Toxicity as Second-Line Therapy After Nivolumab–Ipilimumab in Pleural Mesothelioma
– Pembrolizumab combined with lenvatinib achieved an objective response rate (ORR) of 60% (12 of 20; 95% CI 36–81%) in patients with pleural mesothelioma who progressed after first‑line nivolumab plus ipilimumab.
– Median follow‑up was 11.9 months (IQR 10.8–15.8). Grade 3–4 treatment‑related adverse events (TRAEs) occurred in 70% of patients; common grade 3 events included hypertension (25%) and fatigue/malaise (20%).
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
