Neoadjuvant TAR-200 (intravesical gemcitabine) plus cetrelimab shows improved pathologic responses and MRD signal utility in cisplatin-ineligible MIBC: Primary SunRISe-4 analysis
– In SunRISe-4, neoadjuvant TAR-200 (gemcitabine intravesical system) plus the PD‑1 antibody cetrelimab produced a pathologic complete response (pCR) rate of 38% and pathological overall response (pOR; ≤ypT1N0) of 53% in patients with cT2–T4a N0M0 muscle‑invasive bladder cancer (MIBC) who were ineligible for or refused cisplatin.
– Cetrelimab monotherapy yielded lower pCR (28%) and pOR (44%) rates; 1‑year recurrence‑free survival (RFS) was 77% with the combination versus 64% with monotherapy.
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