– The PRIME randomized phase 3 trial found no statistically significant reduction in metabolic syndrome (MS) incidence at 18 months with metformin versus placebo in men initiating androgen deprivation therapy (ADT) for prostate cancer.
– Metformin produced modest but statistically significant improvements in body weight, waist circumference (at several time points), and hemoglobin A1c compared with placebo.
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