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Metabolic Health in Pregnancy: Unveiling the Differential Impact of Prenatal Behavioral Interventions on Obesity Phenotypes

MedXY Editorial Team•Oct 7, 2025•Clinical Updates
gestational weight gain

Highlight

  • Maternal obesity metabolic phenotypes—metabolically healthy obesity (MHO) versus metabolically unhealthy obesity (MUO)—influence gestational weight gain (GWG), gestational diabetes incidence, and infant adiposity.
  • Despite intensive behavioral therapy (IBT) aiming to optimize GWG, no differential treatment response was observed between MHO and MUO groups in weight or adverse perinatal outcomes.
  • Maternal metabolic health status exerts a stronger effect on adverse outcomes than GWG alone, highlighting the need for early metabolic optimization during pregnancy.

Study Background and Disease Burden

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