Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis: Insights from the Phase 3 GLISTEN Trial and Related Studies
Highlights
- Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, significantly reduces moderate-to-severe cholestatic pruritus in PBC patients, as demonstrated by the phase 3 GLISTEN trial.
- Therapeutic benefit correlates with dose-dependent reductions in total serum bile acids and improvement in patient-reported quality of life measures.
- Gastrointestinal adverse events, particularly diarrhea, were frequent but generally manageable; no treatment-related deaths were reported.
- Pruritus severity strongly correlates with impaired sleep, depression, and overall health-related quality of life, underscoring the clinical importance of effective antipruritic therapy in PBC.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.