Rare but Real: Higher Risks of Vascular and Inflammatory Disease After SARS‑CoV‑2 Infection Than After BNT162b2 Vaccination in Children and Adolescents

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– In a whole-population English cohort of 13.9 million children and young people (CYP) aged <18 years, first SARS‑CoV‑2 diagnosis was associated with markedly increased risks of rare arterial and venous thrombotic events, thrombocytopenia, myocarditis/pericarditis, and inflammatory syndromes—especially in the first week after diagnosis.

– The risk after infection declined over time but remained elevated beyond 12 months for venous thromboembolism, thrombocytopenia, and myocarditis/pericarditis.