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Allogeneic HCT Rebounds, PTCy Reshapes Donor Choice, and CAR‑T Use Surges: Key Trends from the 2013–2023 CIBMTR Activity Report

MedXY Editorial Team•Nov 12, 2025•Hematology-Oncology
CAR‑TGVHD prophylaxishematopoietic cell transplantationPTCy

Highlights

– Allogeneic HCT activity recovered sharply in 2023 after COVID-era declines, with the largest growth in patients aged 65–74 years (CIBMTR 2013–2023).

– Matched unrelated donors remain the single largest allogeneic donor source (45%), but haploidentical and mismatched unrelated donor use has risen as PTCy-based GVHD prophylaxis has been widely adopted.

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