Elinzanetant for Vasomotor Symptoms in Endocrine Therapy for Breast Cancer: A Phase 3 Evidence Synthesis

MedXY Editorial Team•Oct 4, 2025•OB/GYN & Women's Health

Elinzanetant, a neurokinin 1 and 3 receptor antagonist, significantly reduces moderate-to-severe vasomotor symptoms in women receiving endocrine therapy for HR-positive breast cancer or prevention.
The phase 3 OASIS-4 trial demonstrated robust efficacy at both week 4 and week 12, with sustained symptom reduction over 52 weeks.
Adverse events were mostly mild to moderate; common events included headache, fatigue, and somnolence, with a low incidence of serious adverse events.
This study fills a critical gap in managing vasomotor symptoms within a sensitive oncology population where hormonal and typical menopausal symptom treatments are limited due to cancer recurrence risks.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Elinzanetant, a neurokinin 1 and 3 receptor antagonist, significantly reduces moderate-to-severe vasomotor symptoms in women receiving endocrine therapy for HR-positive breast cancer or prevention.
The phase 3 OASIS-4 trial demonstrated robust efficacy at both week 4 and week 12, with sustained symptom reduction over 52 weeks.
Adverse events were mostly mild to moderate; common events included headache, fatigue, and somnolence, with a low incidence of serious adverse events.
This study fills a critical gap in managing vasomotor symptoms within a sensitive oncology population where hormonal and typical menopausal symptom treatments are limited due to cancer recurrence risks.