Early Clinical Evaluation of Novel Broadly Neutralising Monoclonal Antibodies for HIV-1: Safety, Pharmacokinetics, and Neutralisation Profiles of N6LS, PGDM1400LS, and PGT121.414.LS
Highlights
- Early-phase clinical trials demonstrate good safety and tolerability profiles of novel broadly neutralising antibodies (bNAbs) N6LS, PGDM1400LS, and PGT121.414.LS in healthy adults.
- All bNAbs show extended serum half-lives (approximately 49 to 71 days), supporting less frequent dosing schedules for prophylaxis or therapy.
- Subcutaneous administration is feasible with acceptable bioavailability, enhanced by formulations such as ENHANZE drug product (EDP) for N6LS.
- Neutralisation activity is preserved in vivo, supporting their potential use in combination strategies to prevent or treat HIV-1 infection.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.