Population-based studies reveal specific thresholds of meaningful within-patient change on commonly used clinical outcome assessments (COAs) in early cognitive impairment.
Annualized change thresholds for CDR scale Sum of Boxes (0.49), MMSE (-1.01), and FAQ (1.04) in incident MCI offer benchmarks for interpreting clinical progression.
These data enhance clinical trial planning and evaluation by anchoring COA changes to clinically meaningful functional and cognitive decline early in ADRD.
Mechanistic insights into neurodegeneration underscore the importance of early detection and targeted interventions based on changes in cognition and function.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.