Soluble urokinase plasminogen activator receptor (suPAR) levels are significantly higher in patients with Type 2 Diabetes (T2D) compared to those without.
In patients with Coronary Artery Disease (CAD), suPAR mediates more than 50% of the association between T2D and adverse outcomes, including cardiovascular death and myocardial infarction.
Unlike high-sensitivity C-reactive protein (hs-CRP), suPAR acts as a critical independent mediator of the diabetic cardiovascular risk profile.
These findings suggest that chronic immune activation, rather than just acute-phase inflammation, drives the poor prognosis seen in diabetic patients with heart disease.
Introduction: The Intersection of Metabolic and Vascular Disease
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