Aspirin for Delaying Preterm Birth in High-Risk Preterm Pre-eclampsia Pregnancies: Insights from a Multicenter Randomized Trial in Asia

Low-dose aspirin initiated before 16 weeks gestation reduces early preterm birth by approximately 42% in pregnancies at high risk for preterm pre-eclampsia.
Aspirin use is associated with delaying delivery timing, with more pronounced effects in earlier gestational ages and iatrogenic early preterm births related to pre-eclampsia.
The intervention corresponds with a shift from early to late preterm birth rates and shows benefits in pregnancies complicated by small-for-gestational-age (SGA) neonates.
Findings provide mechanistic insight supporting aspirin’s role in modulating pathways leading to preterm delivery, with clinical implications for targeted prevention strategies in Asia and similar populations.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Low-dose aspirin initiated before 16 weeks gestation reduces early preterm birth by approximately 42% in pregnancies at high risk for preterm pre-eclampsia.
Aspirin use is associated with delaying delivery timing, with more pronounced effects in earlier gestational ages and iatrogenic early preterm births related to pre-eclampsia.
The intervention corresponds with a shift from early to late preterm birth rates and shows benefits in pregnancies complicated by small-for-gestational-age (SGA) neonates.
Findings provide mechanistic insight supporting aspirin’s role in modulating pathways leading to preterm delivery, with clinical implications for targeted prevention strategies in Asia and similar populations.

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