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White Matter Microstructure and Cognitive Decline in Aging and Alzheimer Disease: A Comprehensive Review of Recent Advances
Clinical UpdatesAlzheimer diseasecognitive decline

White Matter Microstructure and Cognitive Decline in Aging and Alzheimer Disease: A Comprehensive Review of Recent Advances

By MedXY|Dec 10, 2025

This review synthesizes recent large-scale multi-cohort studies revealing white matter microstructural abnormalities—especially free water increases—in limbic tracts as critical markers of cognitive decline in aging and Alzheimer’s di

Free Water Collapse in Limbic White Matter Predicts Memory Decline in Aging and Alzheimer Disease
NeurologyAlzheimer diseasediffusion MRI

Free Water Collapse in Limbic White Matter Predicts Memory Decline in Aging and Alzheimer Disease

By MedXY|Dec 10, 2025

A large multisite analysis (n=4,467) finds white matter free water (FW), especially in limbic tracts (cingulum, fornix), strongly associates with cross-sectional cognition and longitudinal decline; FW interacts with amyloid, APOE ε4, and gr

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