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Balancing Stroke and Cardiac Risks: DOACs versus Warfarin in Atrial Fibrillation with Mitral Stenosis
Cardiologyanticoagulation safetymitral stenosis

Balancing Stroke and Cardiac Risks: DOACs versus Warfarin in Atrial Fibrillation with Mitral Stenosis

By MedXY|Aug 11, 2026

This study evaluates the real-world effectiveness and safety of direct oral anticoagulants versus warfarin in Asian patients with atrial fibrillation and mitral stenosis, revealing higher stroke yet lower myocardial infarction risk with DOA

Switching from Warfarin to Direct Oral Anticoagulants in Frail Elderly Asian Patients with Atrial Fibrillation: Insights from a Korean Nationwide Study
Cardiology
anticoagulation
Asian Population

Switching from Warfarin to Direct Oral Anticoagulants in Frail Elderly Asian Patients with Atrial Fibrillation: Insights from a Korean Nationwide Study

By MedXY|Jul 3, 2026

In frail elderly Asian AF patients stable on warfarin, transitioning to DOACs increased risks of bleeding, thromboembolic events, and mortality, emphasizing cautious individualized management.

Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation
CardiologyAsian patientsatrial fibrillation

Standard-Dose DOACs Outperform Warfarin More Strongly in Asian Than Non-Asian Patients With Atrial Fibrillation

By MedXY|Apr 30, 2026

In a patient-level meta-analysis of 10,212 Asian and 61,471 non-Asian AF patients, standard-dose DOACs outperformed warfarin more strongly in Asians, with less stroke, major bleeding, and net clinical harm. Standard-dose therapy was favored

Pharmacist-Led Patient Self-Testing Superior to Usual Care for Warfarin Management in Mechanical Heart Valve Patients: Evidence from a Multicentre RCT in China
CardiologyanticoagulationCardiology

Pharmacist-Led Patient Self-Testing Superior to Usual Care for Warfarin Management in Mechanical Heart Valve Patients: Evidence from a Multicentre RCT in China

By MedXY|Feb 23, 2026

A multicentre RCT in China found that pharmacist-led patient self-testing (PST) significantly improves time in therapeutic range and reduces major bleeding and thromboembolism in patients with mechanical heart valves compared to traditional

Rivaroxaban vs Warfarin in Postcardiac Surgery Atrial Fibrillation: Insights from the NEW-AF Trial
Cardiologyanticoagulationatrial fibrillation

Rivaroxaban vs Warfarin in Postcardiac Surgery Atrial Fibrillation: Insights from the NEW-AF Trial

By MedXY|Oct 9, 2025

The NEW-AF trial compared rivaroxaban and warfarin in new-onset atrial fibrillation after cardiac surgery, finding no difference in length of hospital stay but greater patient convenience and similar safety with rivaroxaban.

Spontaneous Intramuscular Hematoma in a Patient with Warfarin Therapy: A Case Report
Cardiologyanticoagulationcase report

Spontaneous Intramuscular Hematoma in a Patient with Warfarin Therapy: A Case Report

By MedXY|Oct 6, 2025

A 75-year-old male on warfarin presented with spontaneous thigh swelling and pain, diagnosed as spontaneous intramuscular hematoma, successfully managed with supportive care and warfarin reversal.

Optimizing Anticoagulant Therapy in Frail Elderly AF Patients: Insights from the COMBINE-AF Substudy
Cardiologyanticoagulationatrial fibrillation

Optimizing Anticoagulant Therapy in Frail Elderly AF Patients: Insights from the COMBINE-AF Substudy

By MedXY|Oct 3, 2025

Switching frail, elderly atrial fibrillation patients from warfarin to standard-dose DOAC reduced stroke, fatal and intracranial bleeding, and death, though gastrointestinal bleeding increased. Major bleeding and net clinical outcome remain

Higher Risk of Major Gastrointestinal Bleeding with Edoxaban vs Warfarin After TAVR: Insights from the ENVISAGE-TAVI AF Trial
Cardiologyatrial fibrillationEdoxaban

Higher Risk of Major Gastrointestinal Bleeding with Edoxaban vs Warfarin After TAVR: Insights from the ENVISAGE-TAVI AF Trial

By MedXY|Oct 3, 2025

The ENVISAGE-TAVI AF trial found that patients with atrial fibrillation undergoing TAVR had a higher incidence of major gastrointestinal bleeding when treated with edoxaban compared to warfarin, highlighting the importance of risk factor id

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