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Preserved Copeptin Kinetics with Aging: Insights into Water Homeostasis and Hyponatremia Risk in Older Adults
Diabetes & EndocrinologyVasopressincopeptin

Preserved Copeptin Kinetics with Aging: Insights into Water Homeostasis and Hyponatremia Risk in Older Adults

By MedXY|Aug 17, 2026

This study reveals that copeptin kinetics remain mostly intact in healthy aging, but older adults exhibit diminished copeptin suppression after hydration, potentially explaining their increased vulnerability to hyponatremia.

Ultra-Early Versus Early Vasopressin Initiation After Norepinephrine Escalation in Septic Shock: Insights from a Target Trial Emulation
Critical Carecritical care
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septic shock

Ultra-Early Versus Early Vasopressin Initiation After Norepinephrine Escalation in Septic Shock: Insights from a Target Trial Emulation

By MedXY|Aug 12, 2026

This study emulated a target trial to compare ultra-early (0-3h) versus early (>3-6h) vasopressin initiation after norepinephrine escalation in septic shock, revealing significant mortality and renal therapy benefits with ultra-early use

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