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Long-Term Efficacy and ctDNA Dynamics in Early-Stage ERBB2-Positive Breast Cancer Treated with Neoadjuvant Paclitaxel, Trastuzumab, and Pertuzumab: Insights from the DAPHNe Trial

The DAPHNe trial demonstrates excellent 5-year outcomes for stage II–III ERBB2-positive breast cancer patients treated with an abbreviated neoadjuvant paclitaxel, trastuzumab, and pertuzumab regimen, with ultrasensitive ctDNA monitoring sho

Jun 28, 2026
Gastroenterology

Spatial Profiling of Resistance Mechanisms in HER2-Positive Gastric Cancer: Insights from Patient-Matched Analysis

This report examines spatial transcriptomic data from HER2+ gastric cancer patients to identify resistance mechanisms to trastuzumab and T-DXd, including EMT and ERAD pathway activation.

Mar 27, 2026

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