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Incidence and Implications of Early Alloantibody Formation After Trauma Resuscitation With Rh(D)+ Whole Blood Versus Rh(D)- Red Blood Cells

A large retrospective study demonstrates that transfusion of low-titer group O whole blood (LTOWB) in trauma resuscitation carries a low and comparable risk of early red blood cell alloimmunization relative to component therapy, including a

Sep 21, 2026
Anesthesiology

Clotting Factor Concentrates vs Frozen Plasma in Severe Trauma Resuscitation: Insights from the FiiRST-2 Randomized Trial

The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.

Sep 23, 2025

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