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Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial
Neurologydopamine D1 antagonistecopipam

Ecopipam Reduced Relapse Risk in Pediatric Tourette Syndrome Without Metabolic or Extrapyramidal Signal in a Phase 3 Randomized Withdrawal Trial

By MedXY|Jun 5, 2026

In a phase 3 randomized withdrawal trial, ecopipam maintained tic improvement in pediatric Tourette syndrome over 24 weeks and showed a generally favorable safety profile without clinically meaningful weight, metabolic, or drug-induced move

Efficacy and Safety of Ecopipam for Tourette Syndrome: Phase 3 Randomized Clinical Trial
Neurologydopamine D1 antagonistecopipam

Efficacy and Safety of Ecopipam for Tourette Syndrome: Phase 3 Randomized Clinical Trial

By MedXY|Jun 5, 2026

This phase 3 trial found that ecopipam reduced tic relapse and maintained symptom improvement in children and adolescents with Tourette syndrome, with mainly central nervous system side effects and no major weight or metabolic concerns.

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