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A two-center observational study highlights significant risks, including a 40% 30-day mortality rate, when performing endovascular aortic arch repair in patients with a native ascending aorta diameter exceeding 38 mm.
A preclinical and human tissue study shows up-regulation of the hexosamine biosynthetic pathway and downstream integrated stress response in thoracic aortic aneurysm, linking excessive glycosylation to vascular smooth muscle cell dysfunctio
This study identifies CDKL1 gene variants impairing ciliary function as novel genetic contributors to thoracic aortic aneurysm and dissection, highlighting an emerging pathogenic link between cilia biology and vascular disease.