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Gastroenterologytherapeutic targetTNK1

Multiomic Profiling and Machine Learning Reveal Distinct Molecular Subtypes of Cholangiocarcinoma and Identify TNK1 as a Novel Therapeutic Target

By MedXY|Aug 21, 2026

This study delineates three unique molecular subtypes of cholangiocarcinoma via integrated multiomic and machine learning methodologies, highlighting TNK1 kinase as a promising targeted therapy in a metabolic subtype.

Hematology-Oncologytherapeutic target

UBA6: A Novel Therapeutic Vulnerability in VEXAS Syndrome Unveiled by E1 Enzyme Dependency Profiling

By MedXY|Oct 14, 2025

This study characterizes UBA1 mutation effects in VEXAS syndrome and identifies UBA6 as a compensatory enzyme and promising therapeutic target, highlighting selective inhibition to combat mutant hematopoietic clones.