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A population-based cohort study in Sweden found that use of 5α-reductase inhibitors, which reduce bioactive testosterone, is associated with a 17% lower risk of laryngeal and hypopharyngeal squamous cell carcinoma in men, supporting the hor
A stakeholder consensus sets a roadmap to develop standardized, age- and sex-specific testosterone reference intervals for women, adolescent girls, and children to improve diagnosis and care for androgen-related disorders.
A longitudinal analysis of the Look AHEAD trial demonstrates that baseline testosterone and weight loss-induced changes in SHBG significantly modulate cardiovascular risk in men with type 2 diabetes, highlighting the critical role of hormon
In a large UK Biobank cohort, higher circulating testosterone was associated with lower prevalent and incident knee osteoarthritis (KOA) in middle-aged and older women, while SHBG and estradiol showed no clear associations.
Testosterone therapy offers modest benefits for sexual function, anemia, and bone health in older men with hypogonadism, but increases risks of venous thromboembolism, fractures, and arrhythmias. Careful patient selection and individualized
