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Tavapadon in Early Parkinson’s Disease: Promising Phase 3 Trial Highlights Safety and Motor Symptom Benefits

The phase 3 TEMPO-2 trial demonstrates that flexible-dose tavapadon, a selective D1/D5 dopamine receptor agonist, significantly improves motor symptoms in early Parkinson’s disease with a manageable safety profile, warranting further

Aug 9, 2026Sign in to read
Neurology

Fixed-Dose Tavapadon for Early Parkinson Disease: A Randomized Clinical Trial

In a phase 3 trial, once-daily tavapadon improved motor symptoms in people with early Parkinson disease and was generally well tolerated, with nausea, headache, and dizziness as the most common side effects.

May 20, 2026Sign in to read
Clinical Updates

Selective D1/D5 Receptor Agonism in Parkinson Disease: Insights from the TEMPO-3 Phase 3 Trial of Tavapadon

The Phase 3 TEMPO-3 trial demonstrates that tavapadon, a novel selective D1/D5 agonist, significantly improves daily ‘good-on-time’ and reduces ‘off-time’ in Parkinson’s disease patients with motor fluctuations, pres

Mar 27, 2026Sign in to read
Neurology

Selective D1/D5 Agonism: TEMPO-3 Trial Positions Tavapadon as a Significant Advancement for Parkinson’s Motor Fluctuations

The Phase 3 TEMPO-3 trial demonstrates that tavapadon, a selective D1/D5 agonist, significantly increases ‘good-on-time’ and reduces ‘off-time’ in Parkinson’s patients with motor fluctuations, offering a favorable sa

Mar 22, 2026Sign in to read

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