
Anesthesiologyopioid use disordertreatment retention
Timing of Initiation of Methadone Take-Home Dosing: Evidence Synthesis and Clinical Implications for Opioid Use Disorder Management
By MedXY|Sep 17, 2026
Early initiation of methadone take-home dosing (5-24 weeks post-induction) reduces mortality and treatment discontinuation, surpassing benefits seen with no take-home dosing. Flexible dosing policies improve retention without increasing ove