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T-cell dysfunction

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Hematology-Oncology

Immunosenescence as a Key Barrier to CD19 CAR T-Cell Therapy in Chronic Lymphocytic Leukemia

This article explores how T-cell immunosenescence impairs the efficacy of CD19 CAR T-cell therapy in chronic lymphocytic leukemia, highlighting potential therapeutic strategies to overcome this barrier.

Aug 27, 2026
Hematology-Oncology

Evolution of Tumor Subclones and T-Cell Dynamics Underlie Variable Ibrutinib Responses in Waldenström Macroglobulinemia

Single-cell profiling of WM during ibrutinib therapy revealed three tumor evolution patterns, a predictive WIP score, and T-cell dysfunction linked to resistance and disease progression.

May 18, 2026Sign in to read

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