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Validating the Virtual Biopsy: Noninvasive Surrogate Endpoints for Disease Progression and Treatment Efficacy in MASH

This review synthesizes the evolving landscape of noninvasive tests (NITs) in MASH, detailing their role as surrogate endpoints for adverse outcomes and therapeutic response based on recent clinical trials and meta-analyses.

Apr 2, 2026
news

Distant Disease‑Free Survival Is a Reliable Surrogate for Overall Survival in Most Neoadjuvant Early Breast Cancer Trials — but Not All Subtypes

A pooled individual‑patient analysis of 11 neoadjuvant RCTs (12,247 patients) finds distant disease‑free survival (DDFS) strongly predicts overall survival (OS) trial‑level effects overall (R2trial=0.91), with weakened surrogacy in hormone‑

Nov 30, 2025Sign in to read
Nephrology

Albuminuria Reduction and GFR Total-Slope Strongly Predict Kidney Failure: Surrogate Endpoints in CKD Trials

Large individual-patient meta-analyses show that 6-month albuminuria reduction and 3-year total GFR slope predict kidney failure across CKD populations—supporting their use as surrogate endpoints in randomized trials with caveats for chroni

Nov 13, 2025
Gastroenterology

Evaluating Surrogate Endpoints in Advanced Biliary Tract Cancer: Progression-Free Survival Outperforms Response Rates as a Predictor of Overall Survival

This comprehensive analysis reveals that progression-free survival moderately correlates with overall survival in advanced biliary tract cancer, while objective response and disease control rates show poor correlation, underscoring the need

Oct 28, 2025Sign in to read

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