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Somatic Hypermutation

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Hematology-Oncology

Gradual Maturation of the B-Cell Receptor Repertoire After Pediatric Hematopoietic Stem Cell Transplantation: Insights into Early Immune Reconstitution

This study reveals early establishment of a diverse naïve B-cell receptor repertoire within 3 months post-pediatric HSCT, followed by gradual antigen-experienced maturation over 24 months, reflecting physiological B-cell development and sup

Sep 18, 2026Sign in to read
Hematology-Oncology

Molecular Mimicry Unveiled: How Somatic Hypermutation and Adenoviral Protein pVII Drive VITT

Researchers have identified that a specific somatic hypermutation (K31E) in the IGLV3-21*02/03 allele triggers VITT by causing antibodies intended for adenoviral protein pVII to cross-react with Platelet Factor 4 (PF4), explaining the patho

Feb 22, 2026

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