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MedXY AI/MedXY News/Tag: Small-vessel disease
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Arterial Spin Labeling Hemodynamic Metrics Predict Cognitive Decline and Small Vessel Disease Progression Over 11 Years
NeurologyNeuroimagingarterial spin labeling

Arterial Spin Labeling Hemodynamic Metrics Predict Cognitive Decline and Small Vessel Disease Progression Over 11 Years

By MedXY|Sep 19, 2026

This study demonstrates that arterial spin labeling spatial coefficient of variation (ASL-sCoV) correlates with cerebral small vessel disease burden and predicts cognitive decline over 11 years, outperforming traditional cerebral blood flow

Unraveling the Link Between Cortical Microinfarcts and Superficial Siderosis in Cerebral Amyloid Angiopathy
NeurologyBệnh động mạch não do amyloid
cortical microinfarcts

Unraveling the Link Between Cortical Microinfarcts and Superficial Siderosis in Cerebral Amyloid Angiopathy

By MedXY|Jul 5, 2026

This study reveals a spatiotemporal relationship between cortical microinfarcts and cortical superficial siderosis in cerebral amyloid angiopathy, suggesting that superficial siderosis may promote local ischemic injury and highlighting a po

Differential Pathophysiological Roles of Centrum Semiovale Perivascular Spaces in Cerebral Amyloid Angiopathy and Deep Perforator Arteriopathy: A Biomarker Synthesis
Clinical UpdatesBệnh động mạch não do amyloidCSF biomarkers

Differential Pathophysiological Roles of Centrum Semiovale Perivascular Spaces in Cerebral Amyloid Angiopathy and Deep Perforator Arteriopathy: A Biomarker Synthesis

By MedXY|Mar 8, 2026

This review synthesizes evidence distinguishing perivascular space enlargement mechanisms in cerebral amyloid angiopathy (CAA) versus deep perforator arteriopathy (DPA), highlighting the diagnostic utility of CSF Aβ42/40 ratios in vascular

Distinct Small Vessel Disease Phenotype Linked to Monoallelic NOTCH3 Loss-of-Function Variants: Differentiation from CADASIL and Clinical Implications
Clinical UpdatesCADASILGenetic Variants

Distinct Small Vessel Disease Phenotype Linked to Monoallelic NOTCH3 Loss-of-Function Variants: Differentiation from CADASIL and Clinical Implications

By MedXY|Oct 6, 2025

Monoallelic NOTCH3 loss-of-function variants cause a subclinical small vessel disease distinct from CADASIL, with white matter changes but lower stroke risk; cardiovascular risk factors and aging exacerbate the phenotype.

Diabetic Peripheral Neuropathy as a Predictor of Lacunar Stroke in Diabetes Patients
Diabetes & EndocrinologydiabetesDiabetic peripheral neuropathy

Diabetic Peripheral Neuropathy as a Predictor of Lacunar Stroke in Diabetes Patients

By MedXY|Oct 2, 2025

A study reveals diabetic peripheral neuropathy (DPN) significantly associates with cerebral small-vessel disease (SVD), indicating a predictive role for lacunar stroke in diabetic patients and highlighting opportunities for early interventi

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