Sleep Medicine

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AD109 (Aroxybutynin and Atomoxetine): A Promising Oral Therapy for Obstructive Sleep Apnea in PAP-Intolerant Patients

The SynAIRgy phase 3 trial demonstrated that the fixed-dose combination of aroxybutynin and atomoxetine (AD109) significantly reduces airway obstruction and improves oxygenation in obstructive sleep apnea patients unable to tolerate positiv

Jul 2, 2026

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Beyond Monotherapy: Combined High-Intensity Circuit Training and Sleep Health Intervention Synergistically Enhances Sleep and Cardiometabolic Outcomes

A randomized clinical trial demonstrates that combining high-intensity circuit training (HICT) with sleep health (SH) counseling significantly outperforms mono-interventions in improving sleep efficiency, reducing wakefulness, and enhancing

Feb 23, 2026

Neurology

Scalable Solutions for Sleep: Converging Evidence from a Nationwide RCT and Meta-Analysis Validates Digital CBT-I

This article analyzes a nationwide decentralized RCT and a systematic meta-analysis to evaluate the efficacy of digital Cognitive Behavioral Therapy for Insomnia (CBT-I), highlighting its role as a scalable, evidence-based first-line treatm

Dec 21, 2025