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Infectious Diseasescervical cancer preventionHPV vaccine

One Dose of HPV Vaccine Noninferior to Two: Implications for Global Cervical Cancer Prevention

By MedXY|Dec 3, 2025

A randomized trial of 20,330 girls 12–16 years shows one dose of bivalent or nonavalent HPV vaccine prevents persistent HPV16/18 infection as effectively as two doses over 5 years, with high effectiveness and no safety signals.

Infectious DiseasesHPV vaccineimmunobridging

Single-dose Cervarix induces durable seropositivity but fails HPV‑16 GMC non-inferiority versus three-dose Gardasil-4: implications from the PRIMAVERA immunobridging trial

By MedXY|Nov 24, 2025

PRIMAVERA immunobridging shows single-dose Cervarix induces near-universal seropositivity at 36 months and non-inferior HPV-18 antibodies versus three-dose Gardasil-4, but HPV-16 antibody GMCs were lower; results inform but do not yet suppo